Non-Invasive Serological Detection of <Emphasis Type="Italic">Helicobacter pylori</Emphasis> Antigens in Adult Hong Kong Chinese Non-Ulcer Dyspepsia Patients |
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Authors: | Vivian WY Lee Andrew KW Chan Kenneth KC Lee Francis KL Chan |
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Institution: | (1) School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China;(2) Department of Medicine and Therapeutics, Division of Gastroenterology and Hepatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China |
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Abstract: | Objective The aim of our study was to evaluate the accuracy of the serology test kit (Signify H. pylori test), an office-based serological test and to compare relative performances with endoscopy, including biopsy urease tests
(Clotest), histology, and culture when applied to dyspeptic adult patients in Hong Kong Chinese.
Methods Prospective clinical trial was conducted at the Alice Ho Miu ling Nethersole Hospital (AHNH) outpatient endoscopy center from
June to December 2004 and included adult Chinese patients who attended the endoscopy center. A research nurse interviewed
consenting patients and whole blood samples were obtained via simple fingerstick were then and transferred to Signify test
kits. The results were read after 5 minutes. The presence of two distinct lines within the result-reading window was treated
as a positive result; a single distinct line was treated as a negative result. All patients underwent upper gastroduodenal
endoscopy, and antral/antrum gastric biopsy specimens were taken and then processed for microbiological cultures.
Results A total of 384 patients were recruited in the study and 131 (34.7%) patients were tested positive for H. pylori. Among them, 62 patients (47.3%) were detected by the Signify H. pylori test. The Signify serology test kit was 52.7% sensitive, 87.9% specific, and 75.7% accurate, respectively in the current
study.
Conclusion The Signify H. pylori test showed a sub-optimal correlation between the presence of H. pylori infection and the serological test results in a Hong Kong Chinese population. |
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