Arabidopsis PWWP domain proteins mediate H3K27 trimethylation on FLC and regulate flowering time |
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| Authors: | Jin‐Xing Zhou Zhang‐Wei Liu Yong‐Qiang Li Lin Li Bangjun Wang She Chen Xin‐Jian He |
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| Institution: | 1. College of Life Sciences, Beijing Normal University, Beijing 100875, China;2. National Institute of Biological Sciences, Beijing 102206, China;3. Key Laboratory of Eco‐Environments in Three Gorges Reservoir Region (Ministry of Education), College of Life Sciences, Southwest University, Chongqing 400715, China |
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| Abstract: | LHP_1 mediates recruitment of the PRC_2 histone methyltransferase complex to chromatin and thereby facilitates maintenance of H_3 K_(27)me_3 on FLC, a key flowering repressor gene. Here, we report that the PWWP domain proteins(PDPs) interact with FVE and MSI5 to suppress FLC expression and thereby promote flowering. We demonstrated that FVE, MSI_5, and PDP_3 were co-purified with LHP_1. The H_3K_(27)me_3 level on FLC was decreased in the pdp mutants as well as in the fve/msi_5 double mutant. This study suggests that PDPs function together with FVE and MSI_5 to regulate the function of the PRC_2 complex on FLC. |
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