衰老的分子机制与干预研究的最新进展

随着全球老龄化时代的到来,衰老和衰老相关疾病带来的健康问题日益突出。如何最大限度地维持老龄人口健康、干预衰老相关疾病并延缓衰老的发生对于医疗系统、科研机构乃至整个社会都是巨大的挑战。目前,对于衰老的分子机制研究已经有长足的进步,对于衰老进程的生物学和遗传学机制已有突破性的认识,对于衰老相关疾病的发病机制也有了深刻的理解。但这些研究成果还远远达不到能够延缓人类衰老并遏制衰老相关疾病的发生的要求。该文将从衰老的分子机制和干预手段这两个方面入手,综述衰老的理论研究和实际应用中的主要成果和最新进展。

Advances in the Research of the Mechanism and Intervention of Aging

The world has heralded the coming of an aging era and the health issues of aging and aging-related diseases have become inevitable challenges to all countries. The key challenges to the health system, research institutions and the society are how to maintain healthy aging, how to intervene the development of aging-related diseases and how to slow down the aging process. In the past few decades, there have been tremendous advances in comprehending the molecular mechanism of aging, the biology and genetics of aging and the pathogenesis of aging-related diseases. However, these research advances have not attained to the ultimate goal in slowing down aging process in humans and curing aging-related diseases. This review will summarize most recent advances in the research of aging with a focus on the molecular mechanism and intervention strategies.