| ATP依赖的Lon蛋白酶研究进展 |
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| 引用本文： | 夏雷,刘永章,姚蔚,黎真,张纪亮,武芝,陈林,吕斌.ATP依赖的Lon蛋白酶研究进展[J].细胞生物学杂志,2012(7):713-720. |
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| 作者姓名： | 夏雷 刘永章 姚蔚 黎真 张纪亮 武芝 陈林 吕斌 |
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| 作者单位： | 温州医学院Attardi线粒体生物医学研究院,浙江省医学遗传学重点实验室,温州医学院检验医学与生命科学学院生物系,温州325035 |
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| 基金项目： | 国家自然科学基金（No.31070710,No.31171345）、浙江省钱江人才B基金（No.2010R10045）、温州医学院科研启动基金（No.QTJ09010）、教育部留学回国人员科研启动基金、温州市科技局对外合作基金（No.H20100064）和浙江省自然科学基金（No.Y2110097）资助项目 |
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| 摘 要： | Lon蛋白酶，也叫蛋白酶La，是一种同质寡聚环状的ATP依赖的蛋白酶，在古生菌、原核生物和真核生物中高度保守。Lon蛋白酶属于AAA＋超家族（与多种细胞活性相关的ATP酶）。自Lon蛋白酶被发现以来，许多研究表明Lon的蛋白酶活性对于维持细胞体内平衡、蛋白质量控制和代谢调控起着重要作用。该文综述了近年来Lon蛋白酶的研究进展，主要从Lon蛋白酶的结构和功能、与衰老和疾病的关系等方面进行了系统的阐述。
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| 关 键 词： | AAA＋蛋白酶 Lon蛋白酶 线粒体 衰老 蛋白质量控制 |
Progress on the Studies of ATP-dependent Lon Protease |
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| Institution: | Xia Lei, Liu Yongzhang, Yao Wei, Li Zhen, Zhang Jiliang, Wu Zhi, Chen Lin, Lu Bin(Attardi Institute of Mitochondrial Biomedicine, Zhejiang Key Laboratory of Medieal Genetics, Department of Biolog) School of Laboratory Medicine and Life Science, Wenzhou Medical College, Wenzhou 325035, China) |
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| Abstract: | Lon, also known as protease La, is a homo-oligomeric ring-shaped ATP-dependent protease which is highly conserved among archaea, prokaryotes and eukaryotes. Lon is a member of the superfamily of ATPase （AAA＋ ATPase） which is associated with diverse cellular activities. Since its first discovery, the Lon protease was found to play an important role in cellular homeostasis, mitochondrial protein quality control and metabolic regulation. In this review, we summarized recent advances in the studies of the ATP-dependent Lon protease. We focused on its structure, function in protein quality control, as well as its involvement in aging and diseases. Research achievements in model organisms will also be covered. |
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| Keywords: | AAA＋ protease Lon protease mitochondria ageing protein quality control |
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