| SUMO化修饰在DNA损伤响应中的作用 |
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| 引用本文： | 蒋华东,李钰. SUMO化修饰在DNA损伤响应中的作用[J]. 细胞生物学杂志, 2012, 0(10): 1049-1054 |
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| 作者姓名： | 蒋华东 李钰 |
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| 作者单位： | 哈尔滨工业大学生命科学与技术学院,哈尔滨150001 |
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| 基金项目： | 国家自然科学基金fN0.31171252）资助项目 |
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| 摘 要： | 物理或化学等多种因素均可以引起DNA损伤。为维持机体基因组的稳定性，机体形成了精确完整的机制来修复损伤的／DNA。SUMO（smallubiquitin-relatedmodifier,SUMO）化修饰与其他蛋白翻译后修饰一样，具有多种生物学功能。近年来的研究表明，其在DNA损伤修复中也具有非常重要的作用。该文就DNA损伤修复、SUMO,96修饰系统及其二者关系的最新研究进展作了较为全面的介绍和总结。
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| 关 键 词： | DNA修复 DNA损伤响应 SUMO化修饰 |
DNA Damage Response and SUMO Modification |
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| Jiang Huadong,Li Yu. DNA Damage Response and SUMO Modification[J]. Chinese Journal of Cell Biology, 2012, 0(10): 1049-1054 |
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| Authors: | Jiang Huadong Li Yu |
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| Affiliation: | (School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China) |
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| Abstract: | DNA damage can be produced widely in our body by physical and/or chemical factors. There fore, in order to maintain the genomic integrity, DNA must be protected from DNA damage and repaired correctly by forming accurate mechanism if DNA damage happened. SUMOylation has multiple biological functions like other post-translation modification. Emerging evidence has showed that SUMOs play vital roles in DNA damage repair. This review focuses on the newly research about DNA damage, SUMOylation and the relationship between them and provides a complete introducing and summarization. |
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| Keywords: | DNA repair DNA damage response SUMOylation |
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