The effect of tunicamycin on transferrin synthesis and secretion in hormonally stimulated explants of rabbit mammary gland |
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| Authors: | Judith P. Bradshaw David A. White |
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| Affiliation: | 1. Department of Biochemistry, University of Nottingham Medical School, Queen's Medical Centre, NG7 2UH, Nottingham, U.K.
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| Abstract: | Pregnant rabbit mammary gland explants cultured with insulin, prolactin and cortisol synthesize and secrete transferrin radiolabelled with [3H]leucine or [3H]mannose. Addition of tunicamycin inhibits the glycosylation but not synthesis of the [3H]leucine-labelled polypeptide. Secretion of the non-glycosylated protein is only marginally inhibited. |
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