A genetic study of two calcium-independent cytosolic PLA2 genes in schizophrenia |
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Authors: | Yu Yaqin Tao Ran Shi Jieping Zhang Xiaojuan Kou Changgui Guo Yingjun Zhang Xuan Lin Xie Liu Shuzheng Ju Guizhi Xu Qi Shang Hong Shen Yan Wei Jun |
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Affiliation: | Jilin University Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun, China. |
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Abstract: | The present study detected 9 single nucleotide polymorphisms (SNPs) at the PLA2G4C and PLA2G6 loci among 240 Chinese parent-offspring trios of Han descent. Of these 9 SNPs, 5 showed highly polymorphic in the Chinese population. They were then applied as genetic markers to test the genetic association of these two calcium-independent cytosolic PLA2 genes with schizophrenia. The transmission disequilibrium test (TDT) showed that rs1549637 at the PLA2G4C locus was the only SNP associated with the illness (chi(2) = 5.63, P = 0.018). The global P-value was 0.082 for 1000 permutations with the TDT analysis. Neither the conditional on allele test nor the conditional on genotype test showed a disease association for the combination of these two genes. Because the PLA2G4C association is so weak, this initial finding should be interpreted with caution. |
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