Resveratrol in cell fate decisions |
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Authors: | Andrea Lisa Holme Shazib Pervaiz |
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Affiliation: | (1) ROS Biology and Apoptosis Group, National University Medical Institutes, National University of Singapore, Singapore, 117597, Singapore;(2) Department of Physiology, Yong Loo Lin School of Medicine, and NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 2 Medical Drive, MD9 #03-06, Singapore, 117597, Singapore;(3) Yong Loo Lin School of Medicine, National University of Singapore, 2 Medical Drive, MD9 #03-06, Singapore, Singapore, 117597;(4) NUS Graduate School of Integrative Sciences and Engineering, National University of Singapore, 2 Medical Drive, MD9 #03-06, Singapore, 117597, Singapore |
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Abstract: | Resveratrol, a polyphenolic phytoalexin, is one of the most extensively studied natural products, with wide ranging biological activity and tremendous clinical potential. First identified from fruits and plants, in particular grapes and wines, its positive effects on a variety of disease states have been unraveled over the past decade or so. Most noticeable are its anti-thrombogenic, anti-inflammatory, cardio-protective, neuro-protective, anti-aging, and cancer preventive and therapeutic activities. Recent data also indicate that depending upon the concentration/dose, resveratrol can trigger or block cell death signaling in tumor cells. Considering the heightened interest in this compound, here we present a short review on the biological activity of this remarkable compound, with a specific focus on its effects on cell survival and death signals. |
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Keywords: | Resveratrol Mitochondria Apoptosis ROS |
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