Structure-activity studies of oxazolidinone analogs as RNA-binding agents |
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| Authors: | Means John Katz Steven Nayek Abhijit Anupam Rajaneesh Hines Jennifer V Bergmeier Stephen C |
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| Affiliation: | Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, USA. |
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| Abstract: | We have synthesized and tested a series of novel 3,4,5-tri- and 4,5-disubstituted oxazolidinones for their ability to bind two structurally related T box antiterminator model RNAs. We have found that optimal binding selectivity is found in a small group of 4,5-disubstituted oxazolidinones. |
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