Molecular characterization of HAO3, the homologue of the Bm86 tick vaccine antigen,from the Iranian isolate of Hyalomma anatolicum anatolicum |
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| Authors: | Seyyed Mahmoud Ebrahimi Habib Paykari Arash Memarnejadian |
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| Affiliation: | 1. Department of Biotechnology, Razi Vaccine and Serum Research Institute (RVSRI), P.O. Box 31975/148, Karaj, Tehran, Iran;2. Department of Parasitology, Razi Vaccine and Serum Research Institute (RVSRI), P.O. Box 31975/148, Karaj, Tehran, Iran;3. Department of Hepatitis and AIDS, Pasteur Institute of Iran, Pasteur Ave., Tehran 1316943551, Iran |
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| Abstract: | Hyalomma anatolicum anatolicum tick is widely distributed in many parts of Iran and while the commercial vaccines based on the application of midgut-derived recombinant Bm86 antigen are used for its control, limited information about the efficiency of this vaccination in Iran is available. Herein, with the final aim of evaluation of Bm86-based heterologous vaccination, as the primary step the Bm86 homologue of the H. a. anatolicum (Hao3) from an Iranian isolate was characterized and compared with the commercialized Bm86 and other Bm86 homologoue sequences available in GenBank. |
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| Keywords: | EGF-like domain Hyalomma anatolicum anatolicum Vaccine candidate Hao3 molecule Tick |
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