miR-338-3p suppresses neuroblastoma proliferation,invasion and migration through targeting PREX2a |
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Authors: | Xin Chen Min Pan Lulu Han Hongting Lu Xiwei Hao Qian Dong |
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Institution: | 1. Department of Pediatric Surgery, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong, China;2. Normal College, Qingdao University, Qingdao, Shandong, China |
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Abstract: | MicroRNAs (miRNA) can regulate cancer cell proliferation and metastasis. Here, we show that miR-338-3p is down-regulated in metastatic tumor tissues compared to primary tumors, and that that miR-338-3p can inhibit cell proliferation by inducing cell cycle arrest, as well as restrain cell migration and invasion. PREX2a is confirmed as a direct target of miR-338-3p. Knockdown of PREX2a inhibits cell proliferation, migration and invasion through the PTEN/Akt pathway. miR-338-3p-dependent inhibition of proliferation and invasion can be rescued by PREXa. Overall, this study demonstrates that miR-338-3p affects the PTEN/Akt pathway by down-regulating PREX2a. This newly identified function of miR-338-3p provides novel insights into neuroblastoma and may foster therapeutic applications. |
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Keywords: | miR-338-3p PREX2a PTEN AKT Neuroblastoma Metastasis Microarray |
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