Role of phospholemman and the 70 kDa inhibitor protein in regulating Na/K ATPase activity in pulmonary artery smooth muscle cells under U46619 stimulation |
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Authors: | Kuntal Dey Sayed Modinur RahamanTapati Chakraborti Sajal Chakraborti |
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Institution: | Department of Biochemistry and Biophysics, University of Kalyani, Kalyani 741235, West Bengal, India |
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Abstract: | Treatment of bovine pulmonary smooth muscle cells with U46619 inhibited the Na+/K+ ATPase activity in two parallel pathways: one of which is mediated via glutathionylation of the pump and the other by augmenting the inhibitory activity of the 70 kDa inhibitor protein of Na+/K+ ATPase. Although phospholemman deglutathionylates the pump leading to its activation, the inhibitor is responsible for irreversible inhibition of Na+/K+ ATPase in an isoform specific manner during treatment of the cells with U46619. |
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Keywords: | TxA2 U46619 Na+/K+ ATPase Phospholemman Inhibitor protein Protein kinase |
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