Hsa-miR-125b suppresses bladder cancer development by down-regulating oncogene SIRT7 and oncogenic long non-coding RNA MALAT1 |
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| Authors: | Yonghua Han Yuchen Liu Hu Zhang Tiantian Wang Ruiying Diao Zhimao Jiang Yaoting Gui Zhiming Cai |
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| Affiliation: | 1. Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People’s Hospital, Postdoctoral Scientific Research Base, Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen, China;2. Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen 518036, China |
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| Abstract: | MicroRNAs mainly inhibit coding genes and long non-coding RNA expression. Here, we report that hsa-miR-125b and oncogene SIRT7/oncogenic long non-coding RNA MALAT1 were inversely expressed in bladder cancer. Hsa-miR-125b mimic down-regulated, whereas hsa-miR-125b inhibitor up-regulated the expression of SIRT7 and MALAT1. Binding sites were confirmed between hsa-miR-125b and SIRT7/MALAT1. Up-regulation of hsa-miR-125b or down-regulation of SIRT7 inhibited proliferation, motility and increased apoptosis. The effects of up-regulation of hsa-miR-125b were similar to that of silencing MALAT1 in bladder cancer as we had previously described. These data suggest that hsa-miR-125b suppresses bladder cancer development via inhibiting SIRT7 and MALAT1. |
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| Keywords: | Bladder cancer MicroRNA Hsa-miR-125b SIRT7 Long non-coding RNA MALAT1 |
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