In vivo NIRF imaging of tumor targetability of nanosized liposomes in tumor-bearing mice |
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Authors: | Lee Sangmin Lee Seung-Young Park Sangjin Ryu Ju Hee Na Jin Hee Koo Heebeom Lee Kyung Eun Jeon Hyesung Kwon Ick Chan Kim Kwangmeyung Jeong Seo Young |
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Institution: | Department of Life and Nanopharmaceutical Science, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea. |
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Abstract: | To optimize tumor targetability of nanosized liposomes for application as drug carriers, various liposomes are prepared by incorporating different amounts (10, 30, and 50?wt%) of cationic, anionic, and PEGylated lipids into neutral lipid. In vivo near-infrared fluorescence images reveal that PEG-PE/PC liposomes display high tumor accumulation in tumor-bearing mice, while large amounts of DOTAP/PC liposomes are rapidly captured in the liver, resulting in poor tumor accumulation. These results demonstrate that optimization of the surface properties of liposomes is very important for their tumor targetability, and that in vivo imaging techniques are useful in developing and optimizing nanosized liposome-based drug carriers. |
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