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A compatible exon-exon junction database for the identification of exon skipping events using tandem mass spectrum data |
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| Authors: | Fan Mo Xu Hong Feng Gao Lin Du Jun Wang Gilbert S Omenn Biaoyang Lin |
| Institution: | (1) Systems Biology Division, Zhejiang-California Nanosystems Institute (ZCNI) of Zhejiang University, Zhejiang University Huajiachi Campus, 268 Kaixuan Road, Hangzhou, 310029, PR China;(2) Department of General Surgery, The Second Affiliated Hospital, ShanXi Medical University, 382 Wuyi Road, Taiyuan, 030000, PR China;(3) College of Life Science, Zhejiang University, Zijingang Campus, Zijinhua Road, Hangzhou, 310058, PR China;(4) Center for Computational Medicine and Biology, National Center for Integrative Biomedical Informatics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218, USA;(5) Departments of Internal Medicine and Human Genetics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218, USA |
| Abstract: | BackgroundAlternative splicing is an important gene regulation mechanism. It is estimated that about 74% of multi-exon human genes have alternative splicing. High throughput tandem (MS/MS) mass spectrometry provides valuable information for rapidly identifying potentially novel alternatively-spliced protein products from experimental datasets. However, the ability to identify alternative splicing events through tandem mass spectrometry depends on the database against which the spectra are searched. |
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