Knockout of 5-lipoxygenase results in age-dependent anxiety-like behavior in female mice |
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Authors: | Joshi Yash B Praticò Domenico |
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Affiliation: | Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America. |
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Abstract: | BackgroundThe enzyme 5-lipoxygenase (5LO) has been implicated in a variety of neurological and psychiatric disorders including anxiety. Knockout of 5LO has previously been shown to alter anxiety-like behavior in mice at a young age but the effect of 5LO knockout on older animals has not been characterized.Methodology/Principal FindingsHere we used the elevated plus maze behavioral paradigm to measure anxiety-like behavior in female mice lacking 5LO (5LO-KO) at three different ages. Adolescent 5LO-KO animals did not significantly differ from wild-type (WT) animals in anxiety-like behavior. However, adult and older mice exhibited increased anxiety-like behavior compared to WT controls.ConclusionsThese results indicate that 5LO plays a role in the development of the anxiety-like phenotype in an age-dependent manner in female mice. Future work should further investigate this interaction as 5LO may prove to be an important molecular target for the development of novel anxiolytic therapies. |
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