Development of doxorubicin loading platform based albumin-sporopollenin as drug carrier |
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Authors: | Esra Maltas Ilkay Hilal Gubbuk Salih Yildiz |
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Institution: | 1. Department of Chemistry, Selcuk University, 42075 Konya, Turkey;2. Department of Biochemistry, Selcuk University, 42075 Konya, Turkey |
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Abstract: | Albumin is thought as an drug carrier for doxorubicin (DOX). The binding of doxorubicin to albumin was studied on the surface of sporopolleninin (SP) to produce a new drug system based natural materials. Human serum albumin (HSA) was immobilized on SPIONs in 20 mM Tris buffer, 7.4 of pH. Data showed that binding amount of HSA has been found to be as 285.53 µg to the 25 mg of Sporopolleninin which also bounded 319.76 µM of DOX. Binding of protein and drug to Sp were clarified by SEM, EDX and FT-IR analysis. |
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Keywords: | Doxorubicin Magnetic nanoparticles Protein Fluorescence spectroscopy |
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