Exploitation of phage battery in the search for bioactive actinomycetes |
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Authors: | D İpek Kurtböke |
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Institution: | (1) Faculty of Science, Health and Education, University of the Sunshine Coast, Maroochydore DC, Queensland, 4558, Australia |
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Abstract: | Screening of microbial natural products continues to represent an important route to the discovery of novel bioactive compounds
for the development of new therapeutic agents, and actinomycetes are still the major producers of biopharmaceuticals. Selective
isolation of bioactive actinomycete species, in particular the rare ones, has thus become a target for industrial microbiologists.
In this context, bacteriophages have proven to be useful tools as (1) naturally present indicators of under-represented or
rare actinomycete taxa in environmental samples, (2) indicators of the relatedness of bioactive taxa in target-directed search
and discovery, (3) de-selection agents of unwanted taxa on isolation plates in target-specific search for rare actinomycete
taxa, (4) tools in screening assays for specific targets. Against this background, a number of case studies are presented
to illustrate the use of bacteriophages as tools in actinomycete-origin bioactive compound search and discovery programs. |
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Keywords: | |
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