Resolution of 2-nitroalcohols by Burkholderia cepacia lipase-catalyzed enantioselective acylation |
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| Authors: | Na Li Shi-Bin Hu Gui-Ying Feng |
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| Affiliation: | (1) Division of Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, Shaanxi, China;(2) Division of Environmental Engineering, College of Science, Northwest A&F University, Yangling, 712100, Shaanxi, China; |
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| Abstract: | Racemic 2-nitro-1-phenylethanol was resolved by via enantioselective transesterification catalyzed by Burkholderia cepacia lipase. The reaction afforded excellent E values (E > 200) and enantioselectivity (up to >99% enantiomeric excesses [ee]) of both remaining substrates and acetylated product. Moreover, the lipase displayed high enantioselectivity in the resolution of additional 2-nitroalcohols (E up to >200). This method provides an efficient alternative for obtaining enantiopure 2-nitroalcohols. |
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