Fibroblast growth factor 2-functionalized collagen matrices for skeletal muscle tissue engineering |
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| Authors: | Yun Ye-Rang Lee Sujin Jeon Eunyi Kang Wonmo Kim Kook-Hyun Kim Hae-Won Jang Jun-Hyeog |
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| Institution: | (1) Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, South Korea;(2) Department of Biochemistry, College of Medicine, Inha University, Incheon, South Korea;(3) Department of Internal Medicine, College of Medicine, CHA University, Gumi, South Korea;(4) Department of Nanobiomedical Science and WCU Research Center, Dankook University Graduate School, Cheonan, South Korea; |
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| Abstract: | Fibroblast growth factor 2 (FGF2) protein plays important roles in wound healing and tissue regeneration. Collagen is clinically
used for wound care applications. We investigated the potential value of FGF2-functionalized collagen matrices for skeletal
muscle tissue engineering. When C2C12 cells were treated with FGF2, cell adhesion increased after 3 and 5 days compared to
the control (P < 0.05). Wound healing activity of FGF2 was slightly higher than the control through cell migration. Cell proliferation activity
of FGF2-functionalized collagen matrices on C2C12 cells also increased. Taken together, FGF2 stimulated C2C12 myoblast growth
by promoting cell adhesion, proliferation and wound healing activity after injury. The potential effect of FGF2-functionalized
collagen matrices was also observed. Thus FGF2 stimulates skeletal muscle development and regeneration, thereby leading to
potential utility for skeletal muscle tissue engineering. |
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