Association between Age at Diagnosis of Graves' Disease and Variants in Genes Involved in Immune Response |
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| Authors: | Beata Jurecka-Lubieniecka Rafal Ploski Dorota Kula Aleksandra Krol Tomasz Bednarczuk Zofia Kolosza Andrzej Tukiendorf Sylwia Szpak-Ulczok Anita Stanjek-Cichoracka Joanna Polanska Barbara Jarzab |
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| Institution: | 1. Department of Nuclear, Medicine and Endocrine Oncology, Maria Sklodowska-Curie Memorial Cancer, Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland.; 2. Department of Forensic Medicine, Medical University of Warsaw, Warsaw, Poland.; 3. Department of Isotopic Diagnostic and Radiopharmaceutical, Medical University of Silesia, Katowice, Poland.; 4. Institute of Automatic Control, Silesian Technical University, Gliwice, Poland.; University of Cagliari, Italy, |
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| Abstract: | BackgroundGraves'' disease (GD) is a complex disease in which genetic predisposition is modified by environmental factors. The aim of the study was to examine the association between genetic variants in genes encoding proteins involved in immune response and the age at diagnosis of GD.Methods735 GD patients and 1216 healthy controls from Poland were included into the study. Eight genetic variants in the HLA-DRB1, TNF, CTLA4, CD40, NFKb, PTPN22, IL4 and IL10 genes were genotyped. Patients were stratified by the age at diagnosis of GD and the association with genotype was analysed.ResultsPolymorphism in the HLA-DRB1, TNF and CTLA4 genes were associated with GD. The carriers of the HLA DRB1*03 allele were more frequent in patients with age at GD diagnosis ≤30 years than in patients with older age at GD diagnosis.ConclusionsHLADRB1*03 allele is associated with young age at diagnosis of Graves'' disease in polish population. |
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