PGPIPN,a Therapeutic Hexapeptide,Suppressed Human Ovarian Cancer Growth by Targeting BCL2 |
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| Authors: | Wei Wang Fang Gu Cai Wei Yigui Tang Xin Zheng Mingqiang Ren Yide Qin |
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| Affiliation: | 1. Department of Biochemistry & Molecular Biology, Anhui Medical University, Heifei, Anhui, China.; 2. Georgia Health Sciences University Cancer Center, Augusta, Georgia, United States of America.; University of Pittsburgh, United States of America, |
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| Abstract: | Bioactive peptides, either derived from nature resources or synthesized by rational design, have been demonstrated potential for therapeutic agents against numerous human diseases, including cancer. However, the mechanism of therapeutic peptides against cancer has not been well elucidated. Here we show that PGPIPN, a hexapeptide derived from bovine β-casein, inhibited the proliferation of human ovarian cancer cells line SKOV3 as well as the primary ovarian cancer cells in vitro. Consistently, PGPIPIN also decreased tumor growth rate in xenograft ovarian cancer model mice in a dose-dependent manner. Further study demonstrated that the anti-tumor effect of PGPIPN is partially through promoting cell apoptosis by inhibiting BCL2 pathway. Thus, our study suggests that PGPIPN is a potential therapeutic agent for the treatment of ovarian cancer or other types of cancer. |
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