Metabolic Imaging of Human Kidney Triglyceride Content: Reproducibility of Proton Magnetic Resonance Spectroscopy |
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| Authors: | Sebastiaan Hammer Aiko P. J. de Vries Paul de Heer Maurice B. Bizino Ron Wolterbeek Ton J. Rabelink Joost Doornbos Hildo J. Lamb |
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| Affiliation: | 1. Department of Radiology, Leiden University Medical Center (Leiden University), Leiden, The Netherlands.; 2. Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.; 3. Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.; 4. Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands.; University of Illinois at Chicago, United States of America, |
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| Abstract: | ObjectiveTo assess the feasibility of renal proton magnetic resonance spectroscopy for quantification of triglyceride content and to compare spectral quality and reproducibility without and with respiratory motion compensation in vivo.Materials and MethodsThe Institutional Review Board of our institution approved the study protocol, and written informed consent was obtained. After technical optimization, a total of 20 healthy volunteers underwent renal proton magnetic resonance spectroscopy of the renal cortex both without and with respiratory motion compensation and volume tracking. After the first session the subjects were repositioned and the protocol was repeated to assess reproducibility. Spectral quality (linewidth of the water signal) and triglyceride content were quantified. Bland-Altman analyses and a test by Pitman were performed.ResultsLinewidth changed from 11.5±0.4 Hz to 10.7±0.4 Hz (all data pooled, p<0.05), without and with respiratory motion compensation respectively. Mean % triglyceride content in the first and second session without respiratory motion compensation were respectively 0.58±0.12% and 0.51±0.14% (P = NS). Mean % triglyceride content in the first and second session with respiratory motion compensation were respectively 0.44±0.10% and 0.43±0.10% (P = NS between sessions and P = NS compared to measurements with respiratory motion compensation). Bland-Altman analyses showed narrower limits of agreement and a significant difference in the correlated variances (correlation of −0.59, P<0.05).ConclusionMetabolic imaging of the human kidney using renal proton magnetic resonance spectroscopy is a feasible tool to assess cortical triglyceride content in humans in vivo and the use of respiratory motion compensation significantly improves spectral quality and reproducibility. Therefore, respiratory motion compensation seems a necessity for metabolic imaging of renal triglyceride content in vivo. |
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