GSTT1 Null Genotype Contributes to Lung Cancer Risk in Asian Populations: A Meta-Analysis of 23 Studies |
| |
Authors: | Xin Yang Man-Tang Qiu Jing-Wen Hu Xiao-xiao Wang Feng Jiang Rong Yin Lin Xu |
| |
Affiliation: | 1. The First Clinical College of Nanjing Medical University, Nanjing, China.; 2. Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, China.; 3. Department of Bio-statistics, Georgia Health Science University, Augusta, Georgia, United States of America.; 4. The Fourth Clinical College of Nanjing Medical University, Nanjing, China.; Baylor College of Medicine, United States of America, |
| |
Abstract: | BackgroundGenetic variation in glutathione S-transferases (GSTs) may contribute to lung cancer risk. Many studies have investigated the correlation between the Glutathione S-transferase T1 (GSTT1) null genotype and lung cancer risk in Asian population but yielded inconclusive results.Methodology/Principal FindingsWe performed a meta-analysis of 23 studies including 4065 cases and 5390 controls. We assessed the strength of the association of GSTT1 with lung cancer risk and performed sub-group analyses by source of controls, smoking status, histological types, and sample size. A statistically significant correlation between GSTT1 null genotype and lung cancer in Asian population was observed (OR = 1.28, 95% CI = 1.10, 1.49; Pheterogeneity<0.001 and I2 = 62.0%). Sub-group analysis revealed there was a statistically increased lung cancer risk in ever-smokers who carried the GSTT1 null genotype (OR = 1.94, 95% CI = 1.27, 2.96; P heterogeneity = 0.02 and I2 = 58.1%). It was also indicated that GSTT1 null genotype could increase lung cancer risk among population-based studies (OR = 1.25, 95% CI = 1.04, 1.50; Pheterogeneity = 0.003 and I2 = 56.8%). The positive association was also found in studies of sample size (≤500 participants) (OR = 1.34, 95% CI = 1.10, 1.62; Pheterogeneity<0.001 and I2 = 65.4%).ConclusionsThese meta-analysis results suggest that GSTT1 null genotype is associated with a significantly increased risk of lung cancer in Asian population. |
| |
Keywords: | |
|
|