Mei-P26 Cooperates with Bam,Bgcn and Sxl to Promote Early Germline Development in the Drosophila Ovary |
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| Authors: | Yun Li Qiao Zhang Arnaldo Carreira-Rosario Jean Z Maines Dennis M McKearin Michael Buszczak |
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| Institution: | 1. Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America.; 2. Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America.; National Cancer Institute, United States of America, |
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| Abstract: | In the Drosophila female germline, spatially and temporally specific translation of mRNAs governs both stem cell maintenance and the differentiation of their progeny. However, the mechanisms that control and coordinate different modes of translational repression within this lineage remain incompletely understood. Here we present data showing that Mei-P26 associates with Bam, Bgcn and Sxl and nanos mRNA during early cyst development, suggesting that this protein helps to repress the translation of nanos mRNA. Together with recently published studies, these data suggest that Mei-P26 mediates both GSC self-renewal and germline differentiation through distinct modes of translational repression depending on the presence of Bam. |
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