Rapid Gene Expression Changes in Peripheral Blood Lymphocytes upon Practice of a Comprehensive Yoga Program |
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| Authors: | Su Qu Solveig Mjelstad Olafsrud Leonardo A Meza-Zepeda Fahri Saatcioglu |
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| Institution: | 1. Department of Biosciences, University of Oslo, Oslo, Norway.; 2. Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.; 3. Genomics Core Facility, Department of Biosciences, University of Oslo, Oslo, Norway.; South Texas Veterans Health Care System and University of Texas Health Science Center at San Antonio, United States of America, |
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| Abstract: | One of the most common integrative medicine (IM) modalities is yoga and related practices. Previous work has shown that yoga may improve wellness in healthy people and have benefits for patients. However, the mechanisms of how yoga may positively affect the mind-body system are largely unknown. Here we have assessed possible rapid changes in global gene expression profiles in the peripheral blood mononuclear cells (PBMCs) in healthy people that practiced either a comprehensive yoga program or a control regimen. The experimental sessions included gentle yoga postures, breathing exercises, and meditation (Sudarshan Kriya and Related Practices – SK&P) compared with a control regimen of a nature walk and listening to relaxing music. We show that the SK&P program has a rapid and significantly greater effect on gene expression in PBMCs compared with the control regimen. These data suggest that yoga and related practices result in rapid gene expression alterations which may be the basis for their longer term cell biological and higher level health effects. |
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