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Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells
Authors:Jiin-Haur Chuang  Hui-Ching Chuang  Chao-Cheng Huang  Chia-Ling Wu  Yung-Ying Du  Mei-Lang Kung  Chih-Hao Chen  San-Cher Chen  Ming-Hong Tai
Affiliation:(1) Department of Surgery, Division of Pediatric Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan;(2) Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Kaohsiung, Taiwan;(3) Department of Otolaryngology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan;(4) Department of Pathology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan;(5) Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, 804, Taiwan;(6) Division of Neurosurgery, Kaohsiung Veterans General Hospital, Kaohsiung, 813, Taiwan;(7) Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, 804, Taiwan
Abstract:

Background  

Toll-like receptor-3 (TLR-3) is a critical component of innate immune system against dsRNA viruses and is expressed in the central nervous system. However, it remains unknown whether TLR3 may serve as a therapeutic target in human neuroblastoma (NB).
Keywords:neuroblastoma   toll-like receptor 3   poly(I:C)   apoptosis
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