Sendai virus proteins counteracting the host innate immunity |
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Authors: | Kato Atsushi |
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Affiliation: | Department of Virology 3, National Institute of Infectious Diseases 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-0011, Japan. akato@nih.go.jp |
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Abstract: | The nucleotide sequence of Sendai virus (SeV) genome was determined in the 1980's. During the analysis of its cDNA, two mRNAs were found to be transcribed from the P gene; one encoding P protein, the other encoding V protein. In addition, C protein was found to be translated from both/ mRNAs. Though the function of V and C proteins was being unknown for a while, the reverse-genetic technique of paramyxoviruses developed at the latter half of the 1990's gave the light on studying them. The V or C protein-knockout-SeV can be made successfully, indicating that the V and C proteins are nonessential for virus growth, However, V knockout-SeV was cleared from the mouse lungs at the one day post inoculation, and C knockout-SeV was cleared immediately after the inoculation. Both V and C proteins were thus appeared to be important for counteracting host innate immunity generated in the early phase of viral infection. |
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