How Echinococcus granulosus deals with complement |
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Authors: | Ferreira A M Irigoín F Breijo M Sim R B Diáz A |
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Affiliation: | Immunology Department, Faculties of Chemistry and Sciences, University of the Republic, Uruguay. aferrei@bilbo.edu.uy |
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Abstract: | Here, Ana Mar a Ferreira and colleagues discuss the interplay between the larval stages of Echinococcus granulosus and an important effector arm of immunity: the host complement system. During early infection, the parasite activates complement, and hence complement-dependent inflammatory responses. However, on differentiation into the hydatid cyst, the parasite exposes to the host a structure - the cyst wall - that does not activate complement strongly. Mechanisms inhibiting complement activation on the cyst wall have been elucidated, contributing to the understanding of how this large, persistent, tissue-dwelling pathogen controls the inflammatory response. |
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