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RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function
Authors:Yang Yi  Li Lixin  Wong Guang W  Krilis Steven A  Madhusudhan M S  Sali Andrej  Stevens Richard L
Affiliation:Department of Medicine, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.
Abstract:
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