Calreticulin inhibits prion protein PrP-(23-98) aggregation in vitro |
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| Authors: | Shiraishi Noriyuki Inai Yoko Hirano Yoshiaki Ihara Yoshito |
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| Institution: | Department of Nutrition, Tokai Gakuen University, Nagoya, Japan. shiraish@tokaigakuen-u.ac.jp |
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| Abstract: | Because prion protein PrP-(23-98) was recently found to polymerize into amyloid-like and proteinase K-resistant spherical aggregates in the presence of NADPH plus copper ions, we tested to determine whether calreticulin (CRT) inhibits PrP-(23-98) aggregation in vitro. The results indicated that CRT suppressed PrP-(23-98) aggregation, and that CRT-mediated solubilization occurred in the aggregates. |
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