Polyphenols in alcoholic beverages activating constitutive androstane receptor CAR |
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| Authors: | Yao Ruiqing Yasuoka Akihito Kamei Asuka Kitagawa Yoshinori Rogi Tomohiro Taieishi Norifumi Tsuruoka Nobuo Kiso Yoshionobu Misaka Takumi Abe Keiko |
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| Institution: | Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. |
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| Abstract: | The constitutive androstane receptor CAR is a xenosensing nuclear receptor that can be activated by natural polyphenols such as flavonoids and catechins. We examined alcoholic beverage phytochemicals for their ability to activate CAR. HepG2 cells were transfected with CAR expression vector and its reporter gene, and then treated with trans-resveratrol, ellagic acid, β-caryophyllene, myrcene, and xanthohumol. A luciferase assay revealed that ellagic acid and trans-resveratrol activated both human and mouse CAR. Since CAR regulates many genes involved in energy metabolism, the possibility exists that these polyphenols would reduce the risk of certain alcohol-induced metabolic disorders with the help of CAR. |
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