Melanin biosynthesis inhibitors from Tarragon Artemisia dracunculus |
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| Authors: | Yamada Masayoshi Nakamura Kazuhiko Watabe Taeko Ohno Osamu Kawagoshi Masaru Maru Norihito Uotsu Nobuo Chiba Tomohiro Yamaguchi Kohji Uemura Daisuke |
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| Affiliation: | FANCL Research Institute, FANCL Corporation, Yokohama, Japan. |
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| Abstract: | The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10-dynoic acid. The respective EC(50) values for melanin biosynthesis inhibition were 1.8 and 2.3 μg/mL for 1 and 2. |
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