Achillinin A, a cytotoxic guaianolide from the flower of Yarrow, Achillea millefolium |
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| Authors: | Li Yong Zhang Man-Li Cong Bin Wang Si-Ming Dong Mei Sauriol Françoise Huo Chang-Hong Shi Qing-Wen Gu Yu-Cheng Kiyota Hiromasa |
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| Institution: | School of Basic Medicine, Hebei Medical University, Hebei Province, PR China. |
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| Abstract: | Achillinin A (2β,3β-epoxy-1α,4β,10α-trihydroxyguai-11(13)-en-12,6α-olide, 1), a new guaianolide isolated from the flower of Achillea millefolium, exhibited potential antiproliferative activity to A549, RERF-LC-kj and QG-90 cells with 50% inhibitory concentration (IC(50)) values of 5.8, 10 and 0.31 μM, respectively. |
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