首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Neutrophil extracellular traps: casting the NET over pathogenesis
Authors:Wartha Florian  Beiter Katharina  Normark Staffan  Henriques-Normark Birgitta
Institution:1. Department of Bacteriology, Swedish Institute for Infectious Disease Control Nobelsväg 18, SE-171 82 Solna, Solna, Sweden;2. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobelsväg 16, SE-171 77 Stockholm, Sweden
Abstract:Neutrophil extracellular traps (NETs) are considered to be part of the human innate immunity because they trap and kill pathogens. NETs are formed by activated neutrophils and consist of a DNA backbone with embedded antimicrobial peptides and enzymes. They are involved in host defense during pneumococcal pneumonia, streptococcal necrotizing fasciitis, appendicitis and insemination. Recently, bacterial virulence factors that counteract NETs have been identified. These include the degradation of the NET-backbone by DNases enabling the liberation of bacteria from NETs, as well as capsule formation, which reduces bacterial trapping. Furthermore, pathogens can resist NET-mediated killing by adding positive charge to their cell surface.
Keywords:
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号