| LncRNA作为ceRNA调控肿瘤的发生发展 |
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| 引用本文： | 连 瑜,李夏雨,唐艳艳,杨丽婷,李小玲,熊 炜,李桂源,曾朝阳. LncRNA作为ceRNA调控肿瘤的发生发展[J]. 生物化学与生物物理进展, 2016, 43(3): 219-225 |
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| 作者姓名： | 连 瑜 李夏雨 唐艳艳 杨丽婷 李小玲 熊 炜 李桂源 曾朝阳 |
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| 作者单位： | 中南大学湘雅医学院附属肿瘤医院，湖南省肿瘤医院，肿瘤放射治疗转化医学湖南省重点实验室，长沙 410013；中南大学肿瘤研究所，卫生部癌变原理重点实验室及教育部癌变与侵袭原理重点实验室，长沙 410078；中南大学湘雅三医院疾病基因组研究中心，湖南省非可控性炎症与肿瘤重点实验室，长沙 410013,中南大学湘雅三医院疾病基因组研究中心，湖南省非可控性炎症与肿瘤重点实验室，长沙 410013,中南大学肿瘤研究所，卫生部癌变原理重点实验室及教育部癌变与侵袭原理重点实验室，长沙 410078,中南大学肿瘤研究所，卫生部癌变原理重点实验室及教育部癌变与侵袭原理重点实验室，长沙 410078,中南大学湘雅医学院附属肿瘤医院，湖南省肿瘤医院，肿瘤放射治疗转化医学湖南省重点实验室，长沙 410013；中南大学肿瘤研究所，卫生部癌变原理重点实验室及教育部癌变与侵袭原理重点实验室，长沙 410078；中南大学湘雅三医院疾病基因组研究中心，湖南省非可控性炎症与肿瘤重点实验室，长沙 410013,中南大学湘雅医学院附属肿瘤医院，湖南省肿瘤医院，肿瘤放射治疗转化医学湖南省重点实验室，长沙 410013；中南大学肿瘤研究所，卫生部癌变原理重点实验室及教育部癌变与侵袭原理重点实验室，长沙 410078；中南大学湘雅三医院疾病基因组研究中心，湖南省非可控性炎症与肿瘤重点实验室，长沙 410013,中南大学湘雅医学院附属肿瘤医院，湖南省肿瘤医院，肿瘤放射治疗转化医学湖南省重点实验室，长沙 410013；中南大学肿瘤研究所，卫生部癌变原理重点实验室及教育部癌变与侵袭原理重点实验室，长沙 410078；中南大学湘雅三医院疾病基因组研究中心，湖南省非可控性炎症与肿瘤重点实验室，长沙 410013,中南大学湘雅医学院附属肿瘤医院，湖南省肿瘤医院，肿瘤放射治疗转化医学湖南省重点实验室，长沙 410013；中南大学肿瘤研究所，卫生部癌变原理重点实验室及教育部癌变与侵袭原理重点实验室，长沙 410078；中南大学湘雅三医院疾病基因组研究中心，湖南省非可控性炎症与肿瘤重点实验室，长沙 410013 |
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| 基金项目： | 国家自然科学基金(81272298, 81372907, 81301757, 81472531, 81402009, 81528019, 81572787)和湖南省自然科学基金(14JJ1010, 2015JJ1022)资助项目 |
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| 摘 要： | 长链非编码RNA(lncRNA)是长度大于200 bp,不编码蛋白质的内源性RNA分子.近年来的研究表明,lncRNA可以作为一种竞争性内源RNA(competing endogenous RNA,ceRNA)吸附miRNA,参与靶基因的表达调控,从而在肿瘤的发生发展中发挥重要的作用.本文从lncRNA作为ceRNA发挥生物学功能这一角度,概述了相关lncRNA在肿瘤发生发展中的作用及机制.揭秘lncRNA与miRNA在肿瘤发生中的相互作用,将为肿瘤的诊断和治疗提供新思路.
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| 关 键 词： | 长链非编码RNA，microRNA，肿瘤发生 |
| 收稿时间： | 2015-11-29 |
| 修稿时间： | 2016-01-25 |
Long Non-coding RNAs Function as Competing Endogenous RNAs to Regulate Cancer Progression |
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| LIAN Yu,LI Xia-Yu,TANG Yan-Yan,YANG Li-Ting,LI Xiao-Ling,XIONG Wei,LI Gui-Yuan and ZENG Zhao-Yang. Long Non-coding RNAs Function as Competing Endogenous RNAs to Regulate Cancer Progression[J]. Progress In Biochemistry and Biophysics, 2016, 43(3): 219-225 |
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| Authors: | LIAN Yu LI Xia-Yu TANG Yan-Yan YANG Li-Ting LI Xiao-Ling XIONG Wei LI Gui-Yuan ZENG Zhao-Yang |
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| Affiliation: | Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China; Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha 410078, China; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha 410013, China,Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha 410013, China,Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha 410078, China,Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha 410078, China,Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China; Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha 410078, China; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha 410013, China,Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China; Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha 410078, China; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha 410013, China,Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China; Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha 410078, China; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha 410013, China and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China; Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha 410078, China; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha 410013, China |
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| Abstract: | Long non-coding RNAs are defined as endogenous molecules with a length greater than 200 nucleotides and with no apparent coding potential. Recent studies showed that lncRNA could interact with the miRNA as a competing endogenous RNAs (ceRNAs) to participate in the expression regulation of target genes, which exert an importance role in the initiation and progression of tumor. In this review, based on lncRNA functioning as ceRNAs, we described the mechanism and function of some relevant lncRNA in the initiation and progression of tumor. A growing number of researches indicated that the interaction between lncRNA and miRNA in tumor genesis would provide new ideas in tumor diagnosis and treatment. |
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| Keywords: | long non-coding RNAs (lncRNA) microRNA(miRNAs) tumorigenesis |
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