Synthesis of sulfated pectins and their anticoagulant activity |
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Authors: | F. V. Vityazev V. V. Golovchenko O. A. Patova N. N. Drozd V. A. Makarov A. S. Shashkov Yu. S. Ovodov |
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Affiliation: | 1.Institute of Physiology, Komi Science Center,Ural Branch of the Russian Academy of Sciences,Syktyvkar,Russia;2.Hematological Scientific Center,Russian Academy of Medical Sciences,Moscow,Russia;3.Zelinsky Institute of Organic Chemistry,Russian Academy of Sciences,117913,Russia |
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Abstract: | The following pectins were sulfated: bergenan BC (the pectin of Bergenia crassifolia L), lemnan LM (the pectin of Lemna minor L), and galacturonan as a backbone of pectins. Pyridine monomethyl sulfate, pyridine sulfotrioxide, and chlorosulfonic acid were used as reagents for sulfation. Chlorosulfonic acid proved to be the optimal reagent for sulfation of galacturonan and other pectins. Galacturonan and pectin derivatives with different degrees of sulfation were synthesized and their anticoagulant activities were shown to depend on the quantity of sulfate groups in the pectin macromolecules. |
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