Y-SNP haplogroups related to the Yqh+ heteromorphism in the Mexican northwestern population |
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Authors: | ENRIQUE JHONATAN ROMO-MARTÍNEZ GABRIELA MARTÍNEZ-CORTÉS REYNA LUCÍA BARAJAS-TORRES RODRIGO RUBI-CASTELLANOS MARÍA TERESA MAGAÑA-TORRES HÉCTOR RANGEL-VILLALOBOS JUAN RAMÓN GONZÁLEZ-GARCÍA |
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Affiliation: | 1. Departamento de Ingeniería en Biotecnología, Universidad Politécnica de Sinaloa, CP: 82199, Mazatlán, Sinaloa, México 2. Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara, CP: 47810, Ocotlán, Jalisco, México 3. División de Genética, Centro de Investigación Biomédica de Occidente-Instituto Mexicano del Seguro Social, CP: 44340, Guadalajara, Jalisco, México 4. Laboratorio de Genética, Centro de Investigaciones Regionales, Universidad Autónoma de Yucatán, CP: 97225, Mérida, Yucatán, México
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Abstract: | Morphological variation of the Y chromosome has been observed in different populations. This variation is mostly related to the heteromorphic Yq12 band, which is composed of a variable block of constitutive heterochromatin. The Yqh+ heteromorphism has a worldwide frequency of 2.85% and is considered clinically innocuous. The aim of this study was to identify the ancestry of the Yqh+ heteromorphism present in individuals from western Mexico. For this purpose, 17 Y-chromosome single nucleotide polymorphisms were analysed by multiplex polymerase chain reaction and SNaPshot assays. In 28 Yqh+ males, only five haplogroups were observed; with a haplogroup diversity of 0.4841 ± 0.1094, which was less than that observed in a study of unselected Mexican mestizo population. Differences were specifically conferred by the high frequencies of haplogroups R1b1 and P*(xQ,R), and by the absence of the Amerindian haplogroup Q (Q*(xQ1a3a) plus Q1a3a) from the Yqh+ group. This study suggests a post-1492 incorporation for Yqh+ chromosomes into the Mexican northwestern population. |
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