Phenotypic variations of haptoglobin Johnson types |
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| Authors: | Cleve Hartwig Herzog Paul |
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| Institution: | (1) Division of Human Genetics, Department of Medicine, Cornell University Medical College, New York, N. Y.;(2) Institute of Human Genetics, University of Marburg, Germany;(3) Ustav Hematologie a Krevni Transfuse, Prague, Czechoslovakia;(4) The New York Hospital-Cornell Medical Center, 525 East 68th Street, 10021 New York, N. Y., USA |
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| Abstract: | Summary Sera from four individuals with haptoglobin Johnson phenotypes were examined. Polyacrylamide gel electrophoresis revealed minor phenotypic variations between the Johnson types of two members from a Czechoslovakian family and of two unrelated Caucasians from the USA. The subtyping procedure after haptoglobin isolation and reductive cleavage showed Hp  J-polypeptide chains with identical electrophoretic mobilities in the four individuals analyzed. In addition to the Hp J chain two persons had a Hp 1 S chain and two persons had a Hp 1 F chain. The two members of the Czechoslovakian family had, furthermore, a third component with an electrophoretic migration rate intermediate between a common Hp 2 and a common Hp 1 S chain.Supported by U.S.P.H.S. Grant AM 11796-02 and aided by a grant from the Deutsche Forschungsgemeinschaft, Bad Godesberg. |
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