Suppression of the guinea-pig line-10 hepatocarcinoma by a factor(s) released from line-10 cells

Summary A factor or factors released from line-10 hepatocarcinoma cells during mixing in a fluid medium suppressed tumor growth when injected intradermally (ID) with viable line-10 cells to strain-2 guinea-pigs. No suppressive factor was released from other syngeneic normal adult, fetal, or tumor cells. The mechanism behind the tumor suppression was not determined, although antigens derived from line-10 cells were demonstrated in media containing the suppressive factor(s).