Synthesis and cytotoxic activity of A-ring modified betulinic acid derivatives |
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| Authors: | You Young-Jae Kim Yong Nam Nguyen-Hai Ahn Byung-Zun |
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| Affiliation: | College of Pharmacy, Chungnam National University, Taejon 305-764, South Korea. |
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| Abstract: | New A-ring modified betulinic acid derivatives having small steric hindrance were prepared and tested for cytotoxic activity on 3 cancer cell lines: 10 compounds showed stronger cytotoxic activity than betulinic acid. Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at C2 showed strong cytotoxicity. |
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