CC3/TIP30 affects DNA damage repair |
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Authors: | Sylvia Fong Frank King Emma Shtivelman |
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Institution: | (1) BioNovo Inc, 5858 Horton Street, Emeryville, 94608, CA, USA |
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Abstract: | Background The pro-apoptotic protein CC3/TIP30 has an unusual cellular function as an inhibitor of nucleocytoplasmic transport. This
function is likely to be activated under conditions of stress. A number of studies support the notion that CC3 acts as a tumor
and metastasis suppressor in various types of cancer. The yeast homolog of CC3 is likely to be involved in responses to DNA
damage. Here we examined the potential role of CC3 in regulation of cellular responses to genotoxic stress. |
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