| 线粒体腺苷酸转运蛋白 |
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| 引用本文： | 王燕萍 高静. 线粒体腺苷酸转运蛋白[J]. 细胞生物学杂志, 2005, 27(3): 273-276 |
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| 作者姓名： | 王燕萍 高静 |
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| 作者单位： | 南京大学生命科学学院，南京大学医学院，南京大学生命科学学院，南京大学医学院 南京210093，南京210093 |
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| 摘 要： | 腺苷酸转运蛋白(ANT)是32kDa的线粒体内膜蛋白。ANT有双重功能，一方面它能作为一个反向转运载体介导胞浆ADP和线粒体ATP的交换，另一方面，ANT能参与线粒体非特异性PTP的形成而调控细胞凋亡。现就ANT的结构、特性、功能以及ANT活性对细胞凋亡的调控进行综述。
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| 关 键 词： | 线粒体 腺苷酸转运蛋白 结构 生理功能 细胞凋亡 |
| 修稿时间： | 2004-10-24 |
Mitochondrial Adenine Nucleotide Translocator |
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| Yan-Ping Wang,Jing Gao. Mitochondrial Adenine Nucleotide Translocator[J]. Chinese Journal of Cell Biology, 2005, 27(3): 273-276 |
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| Authors: | Yan-Ping Wang Jing Gao |
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| Affiliation: | Yan-Ping Wang,Jing Gao* |
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| Abstract: | Adenine nucleotide translocator (ANT), a 32 kDa protein located in the mitochondrial inner membrane, appears to act as a bi-functional protein. On the one hand, ANT is a vital, specific antiporter which contributes to the exchange of cytosolic ADP and mitochondrial ATP. On the other hand, ANT can participate in the formation of the mitochondrial permeability transition pore (PTP), a nonspecific pore that is an important mediator of apoptosis. This paper summarizes some of the recent advances in the research on the structure, characterization, function of ANT and also the activity of ANT which is related to apoptosis. |
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| Keywords: | mitochondria adenine nucleotide translocator apoptosis |
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