Continued glucose output after re-feeding contributes to glucose intolerance in hyperthyroidism. |
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Authors: | M J Holness and M C Sugden |
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Institution: | Istituto di Chimica Biologica, Facoltà di Scienze MM.FF.NN, Università di Perugia, Italy. |
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Abstract: | 4-Methylumbelliferyl beta-N-acetylglucosaminide 6-sulphate was purified from a mixture containing its unsulphated precursor. The substrate was used to test for the presence of functional alpha-subunits in 'intermediate' forms of human beta-N-acetylhexosaminidase in samples of normal and pregnancy serum and in extracts of placenta and lymphocytes from a patient with common acute lymphoblastic leukaemia. Intermediate forms in these samples had no activity towards 4-methylumbelliferyl beta-N-acetylglucosaminide 6-sulphate, indicating that they lack alpha-subunits. |
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