Biotransformation of β-methyldigitoxin by cell cultures ofDigitalis lanata in airlift and stirred tank reactors |
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| Authors: | Heinrich Spieler A Wilhelm Alfermann Ernst Reinhard |
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| Institution: | 1. Pharmazeutisches Institut (Pharmazeutische Biologie), Universit?t Tübingen, Auf der Morgenstelle 8, D-7400, Tübingen, Germany
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| Abstract: | Summary
Digitalis lanata cells were grown at dif-ferent dissolved-oxygen (DO) levels in 20-1 airlift reactors. A DO level of 30% saturation (using
air for aeration) was found to be optimal for growth and the biotransformation ofβ-methyldigitoxin toβ-methyldigoxin. Product yield was further in-creased by using stirred tank reactors instead of the airlift reactor. |
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