Structure of Bovine P2 Basic Protein: Sequence of a Carboxyterminal Segment That Is a Neuritogen in Rabbits |
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| Authors: | D. L. Hsieh M. J. Weise S. Levit J. M. Powers S. W. Brostoff |
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| Affiliation: | Departments of Neurology and Pathology (Neuropathology), Medical University of South Carolina, Charleston, South Carolina, U.S.A. |
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| Abstract: | The sequence of the carboxyterminal 18 amino acids released by cyanogen bromide digestion of the bovine P2 protein was determined. It has several interesting structural and immunological properties. It contains the only two half-cystines in the molecule that have the capacity to form an intrachain disulfide bond. Using the rabbit as a test animal, this carboxyterminal peptide was capable of producing experimental allergic neuritis. The sequence of this peptide is Val-Val-Glu-Cys-Lys-Met-Lys-Asp-Val-Val-Cys-Thr-Arg-Ile-Tyr-Glu-Lys-Val. |
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| Keywords: | Bovine P2 protein Carboxyterminal segment Myelin Neuritogen |
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