Investigating dynamic and energetic determinants of protein nucleic acid recognition: analysis of the zinc finger zif268-DNA complexes |
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| Authors: | Rubben Torella Elisabetta Moroni Michele Caselle Giulia Morra Giorgio Colombo |
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| Affiliation: | 1.Istituto di Chimica del Riconoscimento Molecolare, CNR,Milano,Italy;2.Dipartimento Fisica Teorica,Università di Torino,Torino,Italy |
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| Abstract: | Background Protein-DNA recognition underlies fundamental biological processes ranging from transcription to replication and modification. Herein, we present a computational study of the sequence modulation of internal dynamic properties and of intraprotein networks of aminoacid interactions that determine the stability and specificity of protein-DNA complexes. |
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