Synthesis of 2-azaspiro[3.3]heptane-derived amino acids: ornitine and GABA analogues |
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Authors: | Dmytro S Radchenko Oleksandr O Grygorenko Igor V Komarov |
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Institution: | (1) Enamine Ltd., Aleksandra Matrosova Street, 23, Kyiv, 01103, Ukraine;(2) Department of Chemistry, Kyiv National Taras Shevchenko University, Volodymyrska Street, 64, Kyiv, 01033, Ukraine;; |
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Abstract: | Synthesis of 6-amino-2-azaspiro3.3]heptane-6-carboxylic acid and 2-azaspiro3.3]heptane-6-carboxylic acid was performed.
Both four-membered rings in the spirocyclic scaffold were constructed by subsequent ring closure of corresponding 1,3-bis-electrophiles
at 1,1-C- or 1,1-N-bis-nucleophiles. The two novel amino acids were added to the family of the sterically constrained amino acids for the use
in chemistry, biochemistry, and drug design. |
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Keywords: | |
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