Appendix: A model of plaque formation |
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| Authors: | Donald A. Kaplan Louis Naumovski Bruce Rothschild R. John Collier |
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| Affiliation: | 1. Department of Microbiology, University of California, Los Angeles, CA 90024 U.S.A.;1. Department of Mathematics, University of California, Los Angeles, CA 90024 U.S.A.;2. The Molecular Biology Institute, University of California, Los Angeles, CA 90024 U.S.A. |
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| Abstract: | Equations describing plaque formation in soft agar have been based on certain simplifying assumptions, for which data are presented. The derived equations permit one to calculate (i) average plaque size as a function of the initial density of indicator cells (Do), (ii) the number of cells lysed per plaque as a function of Do, and (iii) the cumulative number of cells lysed at various stages of plaque development. The calculated values agree well with those determined experimentally. |
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| Keywords: | diphtheria toxin bacteriophage mathematical modeling |
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