New insight into the role of phosphodiesterase 3A in porcine oocyte maturation |
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Authors: | Maxime Sasseville Nancy Côté Christine Guillemette François J Richard |
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Institution: | 1. Centre de Recherche en Biologie de la Reproduction, Département des Sciences Animales, Université Laval, Québec, Canada
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Abstract: | Background The ovulatory surge of gonadotropins triggers oocyte maturation and rupture of the ovarian follicle. The resumption of nuclear
maturation in the oocyte from the prophase stage is characterized by germinal vesicle breakdown (GVBD). It has previously
been shown that specific inhibition of cAMP degradation by PDE3 prevents the resumption of oocyte meiosis. However, no report
has characterized the activity of PDE3 in the porcine oocyte, or the implication of the cAMP-PDE3 pathway in the entire nuclear
maturation process. In this study, PDE3 activity in the oocyte was assessed during in vitro maturation (IVM) and the possible roles of the cAMP-PDE3 pathway in the resumption and progression of meiosis were investigated
in terms of different models of oocyte maturation. |
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